Effect of phenytoin on PI3K/Akt signaling pathway in human gingival fibroblasts
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چکیده
منابع مشابه
Phenytoin stimulation of testosterone metabolism in inflamed human gingival fibroblasts.
17B-ol-3-one, 5( 10)-estren17/3-ol-3-one, an isomer each of 5-estrane-3,17-diol and estradiene-3,17-diol and two isomers each of S( 10)-estren-3-ol-17-one and S( l0)-estrene3,17-diol were identified. None of these steroids was detected in the blank incubated samples. In the blank phenolic fractions traces of oestrone and oestradiol-17P were present. In the post-incubation extracts a definite in...
متن کاملeffect of phenytoin and cyclosporine on il-17 production by gingival fibroblasts of adults and children
background and aims. gingival hyperplasia, a relatively common side effect of antiepileptic and anticonvulsant drugs, occurs in 30‒50% of patients taking phenytoin and 25‒81% of those taking cyclosporine. gingival hyperplasia due to lack of balance between extracellular synthesis and degradation is associated with increased production of il-1b, il-6 and il-8 by gingival fibroblasts. tissue leve...
متن کاملGenotoxic and antiapoptotic effect of nicotine on human gingival fibroblasts.
Growing evidence suggests that nicotine, the addictive component of cigarettes, can have a direct role in tumor development by enhancing cell proliferation and impairing apoptotic process in certain types of human cancer cell lines. Since the correlation between apoptosis and DNA damage is already well documented, we investigated the response of human gingival fibroblasts (HGFs) to nicotine exp...
متن کاملCyclosporin a affects signaling events differentially in human gingival fibroblasts.
Gingival overgrowth is a common side-effect of the administration of cyclosporin A (CSA), phenytoin, and calcium blockers. To identify the signaling mechanisms possibly involved in the overgrowth, we examined how CSA affects the activities of MAP kinases and transcription factors in human gingival fibroblasts (HGF). The HGF were treated with CSA and TNF-alpha or PDGF. DNA-binding activity of NF...
متن کاملEffect of Phenytoin and Age on Gingival Fibroblast Enzymes
OBJECTIVE The alteration of cytokine balance is stated to exert greater influence on gingival overgrowth compared to the direct effect of the drug on the regulation of extracellular matrix metabolism. The current study evaluated the effect of phenytoin on the regulation of collagen, lysyl oxidase and elastin in gingival fibroblasts. MATERIALS AND METHODS Normal human gingival fibroblasts (HGF...
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ژورنال
عنوان ژورنال: Proceedings for Annual Meeting of The Japanese Pharmacological Society
سال: 2020
ISSN: 2435-4953
DOI: 10.1254/jpssuppl.93.0_1-p-083